Professional Experience
Member The Brotman Baty Institute (BBI) 2020-current
Professor Dept. Genome Sciences, U. Washington, Seattle, WA 2008-current
Investigator Howard Hughes Medical Institute 2005-current
Associate Prof. Dept. Genome Sciences, U. Washington, Seattle, WA 2004-2008
Associate Prof. Dept. Genetics, CWRU, Cleveland, OH 2003-2004
Director Bioinformatics Core Facility, Dept. Genetics, CWRU, Cleveland, OH
2002-2004
Assistant Prof. Dept. Genetics, CWRU, Cleveland, OH 1997-2003
Research Affiliate Dept. Human Genetics, Roswell Park Cancer Institute, Buffalo, NY 1997
Postdoctoral Fellow BBRP, Lawrence Livermore National Laboratory, Livermore, CA 1995–1997
Education
Ph.D., Molecular Genetics Baylor College of Medicine, Houston, TX, USA 1995
Ludwig-Maximilians Universität, Munich, Germany1990-1991
B.Sc., Honours, Biology University of Saskatchewan, Saskatoon, Canada 1990
Research Interests
Genomic duplication followed by adaptive mutation is considered one of the primary forces for evolution of new function. Duplicated sequences are also dynamic regions of rapid structural change during the course of chromosome evolution. The long-term goal of my research is to understand the evolution, pathology and mechanism(s) of recent gene duplication and DNA transposition within the human genome. Our work involves the systematic discovery of these regions, the development of methods to assess their variation, the detection of signatures of rapid gene evolution and ultimately the correlation of this genetic variation with phenotypic differences within and between species.
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